New preprint from the Gache lab to which we contributed
The team of Vincent Gache from INMG just recently posted a new preprint studying the roles of the microtubule binding protein MACF1 in myofiber’s nuclei positioning.
Myofibers (the cells of the muscles) are weird cells with lots of nuclei. They have to be at the periphery so the fiber remains healthy. This protein MACF1 helps the nuclei keep their place and maintains the fiber healthy. No MACF1 means damaged muscle fiber and neuromuscular junction. Plus mitochondria get all fragmented, which is where it gets really interesting for us.
This study involved a collaboration between the lab of Vincent Gache, Laurent Schaeffer, Julien Gondin & Vincent Jaquemond from INMG, as well as Christophe Jagla from the GReD in Clermont. We modestly contributed to this consortium, work by Audrey Garcia and Marine Lanfranchi from the team.
You can read the paper following this link to bioRxiv